Vos lab member *Co-first author

  1. Uhl L, Aziba A, Löbbert S*, Russell T, Krenz B, Montesinos F, Kannan T, Valanju OR, Schülein-Völk C, de Martines T, Bolz M, Fleischhauer D, Cossa G, Endres T, Solvie D, Gallant P, Rosenwald A, Maric HM, Papadopoulos D, Vos SM, Eilers, M. MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids. Cell (2026).

  2. Rudnizky S, Murray PJ, Sørensen EW, Koenig TJR, Pangeni S, Merino-Urteaga R, Chhabra H, Caccianini L, Davidson IF, Osorio-Valeriano M, Hook PW, Meneses P, Hao J, Zarb JS, Hatzakis NS, Timp W, Farnung L, Vos SM, Peters JM, Aksimentiev A, Ha T. Ultrafast CTCF dynamics control cohesin barrier function. bioRxiv (2025).

  3. Dehmer M, Trunk K, Gallant P, Fleischhauer D, Müller M, Herold S, Cossa G, Conte F, Koster J, Sauer F, Schülein-Völk C, Ade CP, Vidal R, Kisker C, Versteeg R, Beli P, Vos SM, Eilers M, Büchel G. The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma. Genes and Development (2025).

  4. Welp LM, Wulf A, Chernev A, Horokhovskyi Y, Moshkovskii S, Dybkov O, Neumann P, Pašen M, Siraj A, Raabe M, Göthert H, Walshe JL, Infante DA, de A P Schwarzer AC, Dickmanns A, Johannsson S, Schmitzová J, Wohlgemuth I, Netz E, He Y, Fritzemeier K, Delanghe B, Viner R, Vos SM, Oberbeckmann E, Bohnsack KE, Bohnsack MT, Cramer P, Ficner R, Kohlbacher O, Liepe J, Sachsenberg T, Urlaub H. Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry. Nucleic Acids Research (2025).

  5. Mohamed AA, Wang P, Bartel DP§, Vos SM. The structural basis for RNA slicing by human Argonaute2. Cell Reports (2025).

  6. Fendler NL, Ly J, Welp L, Lu D, Schulte F, Urlaub H, Vos SM. Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing. Nucleic Acids Research (2025).

  7. Wang J, Fendler NL, Shukla A, Wu SY, Challa A, Lee J, Joachimiak LA, Minna JD, Chiang CM, Vos SM, D'Orso I. ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss. Molecular Cell (2024).

  8. Diao AJ, Su BG, Vos SM. Pause Patrol: Negative Elongation Factor's role in Promoter-Proximal Pausing and beyond. Journal of Molecular Biology. (2024)

  9. Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E. Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2. Gut (2024).

  10. Papadopoulos D, Ha S*, Fleischhauer D*, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Rajendra Valanju O, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M. Direct RNA-binding by MYCN mediates feedback from RNA processing to transcription control. Molecular Cell (2024).

  11. Liu Y, Flamier A, Bell GW, Diao AJ, Whitfield TW, Wang H-C, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu XS, Vos SM, Young RA, Jaenisch R. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons Neuron (2024).

  12. Su B, Vos SM. Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Molecular Cell (2024).

  13. Zhao J*, Cato LD*, Arora UP, Bao EL, Bryant SC, Williams N, Jia Y, Goldman SR, Nangalia J, Erb MA, Vos SM, Armstrong SA, Sankaran VG. Inherited blood cancer predisposition through altered transcription elongation Cell (2024).

  14. Markert JW, Vos SM, Farnung L. Structure of the complete S. cerevisiae Rpd3S-nucleosome complex. 10.1038/s41467-023-43968-8 Nature Communications (2023).

  15. Li Y, Fan Q, Xu Z, Lee ER, Cohn J, Demers V, Young Lee J, Yip L, Cianfrocco MA, Vos, SM. Optimized path planning surpasses human efficiency in cryo-EM imaging. eLife (2023) (reviewed pre-print)

  16. Eberhardt E, Mohamed AA, Vos SM, Cianfrocco MA. The N-terminal GTPase of Miro1 regulates oligomer formation. bioRxiv (2022).

  17. Farnung L, Ochmann M, Garg G, Vos SM, Cramer P. Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol Cell. (2022).

  18. Mohamed AA, Vazquez Nunez R, Vos SM. Structural advances in transcription elongation. Curr Opin Struct Biol (2022).

  19. Li Y., Fan Q, Cohn J, Demers V, Young Lee J, Yip L, Cianfrocco MA, Vos, SM. Optimized path planning surpasses human efficiency in cryo-EM imaging. BioRxiv (2022)

  20. Filipovski M, Soffers JHM, Vos SM, Farnung L. Structural basis of nucleosome retention during transcription elongation. Science (2022).

  21. Fan Q, Li Y, Yao Y, Cohn J, Liu S, Vos SM, Cianfrocco MA. CryoRL: Reinforcement Learning Enables Efficient Cryo-EM Data Collection Arxiv (2022).

  22. Farnung L, Vos SM. Assembly of RNA polymerase II transcription initiation complexes. Curr Opin Struct Biol. (2022)

  23. Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts. Molecular Cell (2021).

  24. Vos SM. Chronicles of the human SAGA co-activator complex. Nat Struct Mol Biol. (2021).

  25. Chen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer P. Allosteric transcription stimulation by RNA polymerase II super elongation complex. Molecular Cell (2021).

  26. Vos SM. Understanding transcription across scales: From base pairs to chromosomes. Molecular Cell (2021).

  27. Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R. Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Molecular Cell (2021).

  28. Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP. Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers. Cancer Res. (2021).

  29. Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M. Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Molecular Cell. 2021 Jan 15:S1097-2765(20)30956-4.

  30. Zhang S, Aibara S, Vos SM, Agafonov DE, Lührmann R, Cramer P. Structure of a transcribing RNA polymerase II-U1 snRNP complex.

    Science. (2021) Jan 15;371(6526):305-309.

  31. Vos, SM, Farnung, L, Linden, A, Urlaub, H, & Cramer, P. Structure of Complete Pol II-DSIF-PAF-SPT6 Transcription Complex Reveals RTF1 Allosteric Activation. Nature Structural and Molecular Biology (2020).

  32. Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, & Wolf E. MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Molecular Cell (2019). 

  33. Farnung, L*, Vos, SM*, & Cramer, P. Structure of transcribing RNA polymerase II-nucleosome complex. Nature Communications (2018) *These authors contributed equally.

  34. Vos, SM, Farnung, L, Boehning, M, Linden, A, Urlaub, H, & Cramer, P. Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature 560: 607-612 (2018).

  35. Vos, SM*, Farnung, L*, Urlaub, H, & Cramer, P. Structure of paused transcription complex Pol II-DSIF-NELF. Nature 560: 601-606 (2018). *These authors contributed equally.

  36. Farnung, L, Vos, SM, Wigge, C & Cramer, P. Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature 550: 539–542 (2017).

  37. Battaglia, S*, Lidschreiber, M*, Baejen, C, Torkler, P, Vos, SM, & Cramer, P. RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases. eLife 6, e25637 (2017). *These authors contributed equally. 

  38. Vos, SM*, Pöllmann, D*, Caizzi, L, Hofmann, KB, Rombaut, P, Zimniak, T, Herzog, F, & Cramer, P. Architecture and RNA binding of the human negative elongation factor. eLife 5: e14981 (2016). *These authors contributed equally.

  39. Vos SM, Lyubimov AY, Hershey DM, Schoeffler AJ, Sengupta S, Nagaraja V, &  Berger JM. Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein. Genes & Development 28: 1485–1497 (2014).

  40. Vos SM, Stewart NK, Oakley MG, & Berger JM. Structural basis for the MukB-topoisomerase IV interaction and its functional implications in vivo. The EMBO Journal 32: 2950-2962 (2013).

  41. Vos, SM, Lee, I., & Berger, JM. Distinct Regions of the Escherichia coli ParC C-Terminal Domain are Required for Substrate Discrimination by Topoisomerase IV. Journal of Molecular Biology 425:3029–3045 (2013). Cover.

  42. Vos, SM, Tretter, EM, Schmidt, BH & Berger, JM. All tangled up: how cells direct, manage and exploit topoisomerase function. Nature Reviews Molecular Cell Biology 12: 827-841 (2011).

  43. Li, Y. Stewart, NK, Berger, AJ, Vos, S, Schoeffler, AJ, Berger, JM, Chait, BT, & Oakley, MG. Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction. Proceedings of the National Academy of Sciences USA 107: 18832-18837 (2010).

  44. Vos, SM, Yabsley, MJ & Howerth, EW. Initial sequencing and tissue distribution of Toll-like receptor 3 mRNA in white-tailed deer (Odocoileus virginianus). Journal of Wildlife Diseases 45: 785-790 (2009).